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lipid metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
acetyl-CoA + [acyl-carrier_protein] <=> CoA + acetyl-[acyl-carrier_protein] 2.3.1
2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase III
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
2.7.8.7 holo-[acyl-carrier-protein] synthase







CDP-2,3-bis-(O-phytanyl)-sn-glycerol + D-myo-Inositol_1-phosphate <=> saturated_archaetidylinositol_phosphate + CMP + H+ 2.7.8.39 archaetidylinositol phosphate synthase
2.7.8.B13
5.5.1.4 inositol-3-phosphate synthase



sn-glycerol_3-phosphate + NADP+ <=> D-glyceraldehyde_3-phosphate + NADPH + H+ 1.1.1.149 20alpha-hydroxysteroid dehydrogenase
1.1.1.177 glycerol-3-phosphate 1-dehydrogenase (NADP+)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase





acetyl-CoA + malonyl-[acyl-carrier_protein] + H+ <=> acetoacetyl-[acyl-carrier_protein] + CoA + CO2 2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase III

butyryl-CoA + H2O <=> CoA + Butyrate 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
3.1.2.25 phenylacetyl-CoA hydrolase
3.5.1.51 4-acetamidobutyryl-CoA deacetylase







crotonyl-CoA + reduced_flavodoxin <=> butyryl-CoA + electron_transfer_protein 1.3.8.1 short-chain acyl-CoA dehydrogenase

UDP-glucose + 1,2-diphytanyl-sn-glycero-3-O-beta-D-glucoside <=> UDP + 1,2-diphytanyl-sn-glycero-3-O-(6-O-beta-D-glucosyl)-beta-D-glucoside 2.4.1.B51

malonyl-CoA + [acyl-carrier_protein] <=> CoA + malonyl-[acyl-carrier_protein] 2.3.1
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system




(S)-3-hydroxyhexanoyl-CoA + NAD+ <=> 3-oxohexanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


(3R)-3-hydroxydecanoyl-[acyl-carrier_protein] <=> 2-decenoyl-[acyl-carrier_protein] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





3-(O-geranylgeranyl)-sn-glycerol_1-phosphate + geranylgeranyl_diphosphate <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + diphosphate 2.5.1.42 geranylgeranylglycerol-phosphate geranylgeranyltransferase

3-trans-hexenoyl-CoA <=> trans-2-hexenoyl-CoA 5.3.3.8 Delta3-Delta2-enoyl-CoA isomerase
5.3.3.M5


2-decenoyl-[acyl-carrier_protein] <=> cis-3-decenoyl-[acyl-carrier_protein] 5.3.3.14 trans-2-decenoyl-[acyl-carrier protein] isomerase

L-alpha-glycerophosphate + NADP+ <=> dihydroxyacetone_phosphate + NADPH + H+ 1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.261 sn-glycerol-1-phosphate dehydrogenase
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase









CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine <=> saturated_archaetidylserine + CMP + H+ 2.7.8.38 archaetidylserine synthase

(R)-3-hydroxybutyryl-CoA <=> crotonyl-CoA + H2O 1.1.1.36 acetoacetyl-CoA reductase
3.3.2.12 oxepin-CoA hydrolase


alditol + NAD+ <=> aldose + NADH + H+ 1.1.1
1.1.1.112 indanol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.307 D-xylose reductase
1.1.1.406 galactitol 2-dehydrogenase (L-tagatose-forming)
1.1.1.6 glycerol dehydrogenase
1.1.1.77 lactaldehyde reductase
1.1.1.78 methylglyoxal reductase (NADH)











CoA-[4''-phosphopantetheine] + apo-acyl-carrier_protein <=> adenosine_3'',5''-bisphosphate + [acyl-carrier_protein] 2.7.8
2.7.8.7 holo-[acyl-carrier-protein] synthase


palmitoyl-CoA + NADP+ <=> trans-2-hexadecenoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


palmitoyl-CoA + acceptor <=> trans-2-hexadecenoyl-CoA + reduced_acceptor 1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase


L-alpha-glycerophosphate + geranylgeranyl_diphosphate <=> 3-(O-geranylgeranyl)-sn-glycerol_1-phosphate + diphosphate 2.5.1.41 phosphoglycerol geranylgeranyltransferase

(R)-3-hydroxybutyryl-CoA + NADPH + H+ <=> acetoacetyl-CoA + NADP+ 1.1.1.36 acetoacetyl-CoA reductase

[acyl-carrier_protein] + H2O <=> 4''-phosphopantetheine + apo-acyl-carrier_protein 3.1.4.14 [acyl-carrier-protein] phosphodiesterase

butyryl-CoA + acceptor <=> crotonyl-CoA + reduced_acceptor 1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.99.12 2-methylacyl-CoA dehydrogenase




GTP + Butyrate + CoA <=> GDP + phosphate + butyryl-CoA 6.2.1.10 carboxylic acid---CoA ligase (GDP-forming)

2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + reduced_acceptor <=> 2,3-bis-O-phytanyl-sn-glycerol_1-phosphate + acceptor 1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

butyryl-CoA + O2 <=> crotonyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase
1.3.8.1 short-chain acyl-CoA dehydrogenase


hexanoyl-CoA + O2 <=> trans-2-hexenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

(S)-3-hydroxyhexanoyl-CoA <=> trans-2-hexenoyl-CoA + H2O 4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase



palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase










monoacylglycerol + H2O <=> glycerol + fatty_acid + H+ 3.1.1.23 acylglycerol lipase
3.1.1.3 triacylglycerol lipase
3.1.1.67 fatty-acyl-ethyl-ester synthase
3.1.1.79 hormone-sensitive lipase




alditol + NADP+ <=> aldose + NADPH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.10 L-xylulose reductase
1.1.1.149 20alpha-hydroxysteroid dehydrogenase
1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.188 prostaglandin-F synthase
1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.274 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.307 D-xylose reductase
1.1.1.365 D-galacturonate reductase
1.1.1.372 D/L-glyceraldehyde reductase
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase




















1-archaetidyl-1D-myo-inositol_3-phosphate + H2O <=> 1-archaetidyl-1D-myo-inositol + phosphate 3.1.3.B14

hexanoate + ATP + CoA <=> hexanoyl-CoA + AMP + diphosphate 6.2.1.1 acetate---CoA ligase
6.2.1.12 4-coumarate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase
6.2.1.44 3-(methylthio)propionyl---CoA ligase





CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine <=> saturated_archaetidylserine + CMP + H+ 2.7.8.38 archaetidylserine synthase

trans-trans-2,4-hexadecadienoyl-CoA + NADPH <=> trans-2-hexadecenoyl-CoA + NADP+ 1.3.1.34 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]

trans-2-hexadecenoyl-CoA + NADH <=> palmitoyl-CoA + NAD+ 1.3.1.118 meromycolic acid enoyl-[acyl-carrier-protein] reductase
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)




ADP + phosphate + butyryl-CoA <=> ATP + Butyrate + CoA 6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.5 succinate---CoA ligase (ADP-forming)
6.2.1.56 4-hydroxybutyrate---CoA ligase (ADP-forming)
6.2.1.9 malate---CoA ligase
6.2.1.B11





2,3-bis-O-phytanyl-sn-glycerol_1-phosphate + NADP+ <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + NADPH + H+ 1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]

sn-2-monoacylglycerol <=> monoacylglycerol 0.0.0.0

malonyl-[acyl-carrier_protein] + H+ <=> acetyl-[acyl-carrier_protein] + CO2 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
4.1.1.87 malonyl-S-ACP decarboxylase
4.1.1.M15



alditol + NADP+ <=> aldose + NADPH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.10 L-xylulose reductase
1.1.1.149 20alpha-hydroxysteroid dehydrogenase
1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.188 prostaglandin-F synthase
1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.274 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.307 D-xylose reductase
1.1.1.365 D-galacturonate reductase
1.1.1.372 D/L-glyceraldehyde reductase
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase




















palmitoyl-CoA + O2 <=> trans-2-hexadecenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

(3R)-3-hydroxybutanoyl-[acyl-carrier_protein] + NADP+ <=> acetoacetyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+ 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
6.4.1.4 methylcrotonoyl-CoA carboxylase



phosphatidylcholine + H2O <=> lysophosphatidylcholine + fatty_acid + H+ 3.1.1.26 galactolipase
3.1.1.32 phospholipase A1
3.1.1.4 phospholipase A2
3.1.1.5 lysophospholipase




2,3-bis-(O-geranylgeranyl)-sn-glycerol_1-phosphate + CTP + H+ <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate 2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

hexanoyl-CoA + H2O <=> CoA + hexanoate 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
3.1.2.25 phenylacetyl-CoA hydrolase






Butyrate + CoA + ATP <=> butyryl-CoA + AMP + diphosphate 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase
6.2.1.30 phenylacetate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
6.2.1.44 3-(methylthio)propionyl---CoA ligase







3-trans-Hexadecenoyl-CoA <=> trans-2-hexadecenoyl-CoA 5.3.3.8 Delta3-Delta2-enoyl-CoA isomerase

palmitoleic_acid + ATP + CoA + H+ <=> palmitoleoyl-CoA + AMP + diphosphate + H+ 6.2.1.3 long-chain-fatty-acid---CoA ligase

CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine + CMP + H+ 2.7.8.38 archaetidylserine synthase

S-adenosyl-L-methionine + phospholipid_olefinic_fatty_acid <=> S-adenosyl-L-homocysteine + phospholipid_cyclopropane_fatty_acid 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase

UDP-glucose + archaeol <=> UDP + 1,2-bis-phytanyl-sn-glycero-3-O-beta-D-glucoside 2.4.1.B50

triacylglycerol + H2O <=> diacylglycerol + a_carboxylate 3.1.1.13 sterol esterase
3.1.1.3 triacylglycerol lipase
3.1.1.34 lipoprotein lipase
3.1.1.79 hormone-sensitive lipase




Visualization of the pathway